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dc.contributor.authorHernández-Gorritti, Wilfredo-Román
dc.contributor.authorPaz-Castillo-Berríos, Juan
dc.contributor.authorCarrasco-Solís, Fernando
dc.contributor.authorVaisberg-Wolach, Abraham
dc.contributor.authorSpodine-Spiridonova, Evgenia 
dc.contributor.authorManzur-Saffie, Jorge 
dc.contributor.authorBeyer, Lothar
dc.contributor.otherHernández-Gorritti, Wilfredo-Román
dc.identifier.citationHernández Gorritti, W., Paz Castillo-Berríos, J., Carrasco, F., Vaisberg, A., Spodine, E., Manzur, J., ...y Beyer, L. (2013). Synthesis and characterization of new palladium (ii) thiosemicarbazone complexes and their cytotoxic activity against various human tumor cell lines. Bioinorganic Chemistry and Applications, 2013, 12 p. Recuperado de
dc.descriptionIndexado en Scopuses
dc.description.abstractThe palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2'-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3'-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2'-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1'-nitro-2'-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (–9.87¿M) exhibited higher antiproliferative activity than their free ligands (–70.86 and >250¿M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02¿M, resp.).en_US
dc.publisherHindawi Publishing Corporationen_US
dc.sourceUniversidad de Lima
dc.sourceRepositorio Institucional Ulima
dc.subjectLínea celular tumoralen_US
dc.subjectTécnicas in vitro
dc.subjectCell line, Tumor
dc.subjectIn vitro techniques
dc.subject.classificationCiencias / Química
dc.subject.classificationCiencias / Medicina y salud
dc.titleSynthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Linesen_US
dc.type.otherArtículo en Scopuses_PE
dc.identifier.journalBioinorganic Chemistry and Applications
dc.publisher.countryEstados Unidos
dc.description.peer-reviewRevisión por pares

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