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dc.contributor.authorHernández-Gorritti, Wilfredo-Román
dc.contributor.authorPaz-Castillo-Berríos, Juan
dc.contributor.authorCarrasco-Solís, Fernando
dc.contributor.authorVaisberg-Wolach, Abraham
dc.contributor.authorSpodine-Spiridonova, Evgenia 
dc.contributor.authorManzur-Saffie, Jorge 
dc.contributor.authorBeyer, Lothar
dc.contributor.otherHernández-Gorritti, Wilfredo-Román
dc.date.issued2013
dc.identifier.citationHernández Gorritti, W., Paz Castillo-Berríos, J., Carrasco, F., Vaisberg, A., Spodine, E., Manzur, J., ...y Beyer, L. (2013). Synthesis and characterization of new palladium (ii) thiosemicarbazone complexes and their cytotoxic activity against various human tumor cell lines. Bioinorganic Chemistry and Applications, 2013, 12 p. Recuperado de https://www.hindawi.com/journals/bca/2013/524701/en_US
dc.identifier.isbn978-1-4503-6502-4
dc.identifier.urihttp://repositorio.ulima.edu.pe/handle/123456789/1489
dc.descriptionIndexado en Scopuses
dc.description.abstractThe palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2'-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3'-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2'-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1'-nitro-2'-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (–9.87¿M) exhibited higher antiproliferative activity than their free ligands (–70.86 and >250¿M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02¿M, resp.).en_US
dc.formatapplication/pdf
dc.language.isoengen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/pe/
dc.sourceUniversidad de Lima
dc.sourceRepositorio Institucional Ulima
dc.subjectTiosemicarbazonasen_US
dc.subjectPaladioen_US
dc.subjectLínea celular tumoralen_US
dc.subjectTécnicas in vitro
dc.subjectThiosemicarbazones
dc.subjectPalladium
dc.subjectCell line, Tumor
dc.subjectIn vitro techniques
dc.subject.classificationCiencias / Química
dc.subject.classificationCiencias / Medicina y salud
dc.titleSynthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Linesen_US
dc.typeinfor:eu-repo/semantics/articlees_PE
dc.type.otherArtículo en Scopuses_PE
dc.identifier.journalBioinorganic Chemistry and Applications
dc.publisher.countryEstados Unidos
dc.description.peer-reviewRevisión por pares


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