Mostrar el registro sencillo del ítem
Insights in Osteosarcoma by Proton Nuclear Magnetic Resonance Serum Metabonomics
dc.contributor.author | Quintero Escobar, Melissa | |
dc.contributor.author | da Costa, Tássia B.B.C. | |
dc.contributor.author | Gelain Martins, Lucas | |
dc.contributor.author | Costa, Sílvia Souza Da | |
dc.contributor.author | vanHelvoort Lengert, André | |
dc.contributor.author | Boldrini, Érica | |
dc.contributor.author | Morini da Silva, Sandra Regina | |
dc.contributor.author | Lopes, Luiz Fernando Risso | |
dc.contributor.author | Vidal, Daniel Onofre | |
dc.contributor.author | Krepischi, Ana Cristina Victorino | |
dc.contributor.author | Maschietto, Mariana | |
dc.contributor.author | Tasic, L. | |
dc.contributor.other | Gelain Martins, Lucas | |
dc.date.accessioned | 2020-11-13T16:05:46Z | |
dc.date.available | 2020-11-13T16:05:46Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Quintero Escobar, M., da Costa, T.B.B.C., Martins, L.G., Costa, S.S., vanHelvoort Lengert, A., Boldrini, E., Morini da Silva, S.R., Lopes, L.F., Vidal, D.O., Krepischi, A.C.V., Maschietto, M. & Tasic, L. (2020). Insights in Osteosarcoma by Proton Nuclear Magnetic Resonance Serum Metabonomics. Frontiers in Oncology, 10. https://doi.org/10.3389/fonc.2020.506959 | es_PE |
dc.identifier.issn | 2234-943X | |
dc.identifier.uri | https://hdl.handle.net/20.500.12724/11896 | |
dc.description | Indexado en Scopus | es_PE |
dc.description.abstract | Pediatric osteosarcoma outcomes have improved over the last decades; however, patients who do not achieve a full resection of the tumor, even after aggressive chemotherapy, have the worst prognosis. At a genetic level, osteosarcoma presents many alterations, but there is scarce information on alterations at metabolomic levels. Therefore, an untargeted nuclear magnetic resonance metabonomic approach was used to reveal blood serum alterations, when samples were taken from 21 patients with osteosarcoma aged from 12–20 (18, 86%) to 43 (3, 14%) years before any anticancer therapy were collected. The results showed that metabolites differed greatly between osteosarcoma and healthy control serum samples, especially in lipids, aromatic amino acids (phenylalanine and tyrosine), and histidine concentrations. Besides, most of the loading plots point to protons of the fatty acyls (-CH3 and -CH2-) from very-low- and low-density lipoproteins and cholesterol, as crucial metabolites for discrimination of the patients with osteosarcoma from the healthy samples. The relevance of blood lipids in osteosarcoma was highlighted when analyzed together with the somatic mutations disclosed in tumor samples from the same cohort of patients, where six genes linked to the cholesterol metabolism were found being altered too. The high consistency of the discrimination between osteosarcoma and healthy control blood serum suggests that nuclear magnetic resonance could be successfully applied for osteosarcoma diagnostic and prognostic purposes, which could ameliorate the clinical efficacy of therapy. | es_PE |
dc.format | application/pdf | es_PE |
dc.language.iso | eng | es_PE |
dc.publisher | Frontiers Media S.A. | es_PE |
dc.relation.ispartof | urn:issn:2234-943X | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Repositorio Institucional - Ulima | es_PE |
dc.source | Universidad de Lima | es_PE |
dc.subject | Osteosarcoma en niños | es_PE |
dc.subject | Osteosarcoma | es_PE |
dc.subject | Cáncer en niños | es_PE |
dc.subject | Osteosarcoma in children | es_PE |
dc.subject | Cancer in children | es_PE |
dc.subject | Resonancia magnética nuclear (Medicina) | es_PE |
dc.subject | Nuclear magnetic resonance | es_PE |
dc.title | Insights in Osteosarcoma by Proton Nuclear Magnetic Resonance Serum Metabonomics | es_PE |
dc.type | info:eu-repo/semantics/article | |
dc.description.version | info:eu-repo/semantics/publishedVersion | |
dc.type.other | Artículo en Scopus | es_PE |
ulima.areas.lineasdeinvestigacion | Calidad de vida y bienestar / Salud | es_PE |
dc.identifier.journal | Frontiers in Oncology | es_PE |
dc.publisher.country | CH | es_PE |
dc.description.peer-review | Revisión por pares | es_PE |
dc.subject.ocde | http://purl.org/pe-repo/ocde/ford#2.11.04 | |
dc.identifier.doi | https://doi.org/10.3389/fonc.2020.506959 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
ulima.autor.afiliacion | Facultad de Ingeniería Industrial, Universidad de Lima | es_PE |
ulima.autor.carrera | (No figura en la lista del año 2019) | es_PE |
dc.identifier.isni | 0000000121541816 |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Ingeniería Industrial [204]