Show simple item record

dc.contributor.authorHernández-Gorritti, Wilfredo-Román
dc.contributor.authorVaisberg-Wolach, Abraham
dc.contributor.authorTobar, Mabel
dc.contributor.authorÁlvarez, Melisa
dc.contributor.authorManzur-Saffie, Jorge
dc.contributor.authorEchevarría, Yuri
dc.contributor.authorSpodine-Spiridonova, Evgenia 
dc.contributor.otherHernández-Gorritti, Wilfredo-Románes_PE
dc.date.issued2016
dc.identifier.citationHernández, W., Vaisberg, A., Tobar, M., Álvarez, M., Manzur, J., Echevarría, Y., y Spodine, E. (2016). In vitro antiproliferative activity of palladium (II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles. New Journal of Chemistry, 40(2), 1853-1860. doi:10.1039/c5nj02429cen_EN
dc.identifier.issn1144-0546
dc.identifier.urihttps://hdl.handle.net/20.500.12724/1521
dc.descriptionIndexado en Scopuses_PE
dc.description.abstractThis work reports the synthesis and characterization of palladium(II) complexes Pd(L1)2 (1), Pd(L2)2 (2), Pd(L3)2 (3) and Pd(L4)2 (4), where L1H: 1-naphthaldehyde thiosemicarbazone; L2H: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; L3H: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; L4H: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L1)2 has the most potent activity for all the studied cell lines (IC50 ~ 1 µM), with the exception of H460. Pd(L2)2 is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L4)2 is the complex which exhibits the lowest activity against the same cell line (IC50 ~ 11 µM), being ten times lower than that of Pd(L1)2. These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11–13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L1)2, Pd(L3)2 and Pd(L4)2 show antiproliferative activity against DU-145, while those with Pd(L2)2, Pd(L3)2 and Pd(L4)2 against HuTu80.en_EN
dc.formatapplication/pdf
dc.language.isoenges_ES
dc.publisherThe Royal Society of Chemistry and the Centre National de la Recherche Scientifiquees_ES
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceUniversidad de Lima
dc.sourceRepositorio Institucional Ulima
dc.subjectTiosemicarbazonases_ES
dc.subjectPaladioes_PE
dc.subjectLínea celular tumorales_PE
dc.subjectTécnicas in vitroes_PE
dc.subjectThiosemicarbazonesen_EN
dc.subjectPalladiumen_EN
dc.subjectCell line, Tumoren_EN
dc.subjectIn vitro techniquesen_EN
dc.subject.classificationIngenierías / Ingeniería química
dc.titleIn vitro antiproliferative activity of palladium(II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticleses_ES
dc.typeinfor:eu-repo/semantics/articlees_PE
dc.type.otherArtículo en Scopuses_PE
dc.identifier.journalNew Journal of Chemistry
dc.publisher.countryReino Unidoes
dc.identifier.eissn1369-9261
dc.description.peer-reviewRevisión por pareses_PE


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record