Show simple item record

dc.contributor.authorHernández-Gorritti, Wilfredo-Román
dc.contributor.authorPaz-Castillo-Berríos, Juan
dc.contributor.authorCarrasco-Solís, Fernando
dc.contributor.authorVaisberg-Wolach, Abraham
dc.contributor.authorManzur-Saffie, Jorge 
dc.contributor.authorSpodine-Spiridonova, Evgenia 
dc.contributor.authorBeyer, Lothar
dc.contributor.otherHernández-Gorritti, Wilfredo-Románes_PE
dc.date.issued2010
dc.identifier.citationHernández, W., Paz, J., Carrasco, F., Vaisberg, A., Manzur, J., Spodine, E., ... y Beyer, L. (2010). Synthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lines. Zeitschrift für Naturforschung B, (65)10, 1271–1278. https://doi.org/10.1515/znb-2010-1015
dc.identifier.urihttps://hdl.handle.net/20.500.12724/1522
dc.descriptionIndexado en Scopus
dc.description.abstractWith the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC1, (1), 4-phenyl-1- (5 -phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human tumor cell lines have revealed that the palladium(II) complexes 5– 8 are more cytotoxic (IC50 values in the range of 0.21 – 3.79 µM) than their corresponding ligands (1 – 4) (> 60 µM). These results indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 = 0.21 µM).es_ES
dc.formatapplication/pdfes
dc.language.isoeng
dc.publisherWalter de Gruyter GmbHes_ES
dc.relation.urihttps://doi.org/10.1515/znb-2010-1015
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/pe/
dc.sourceUniversidad de Lima
dc.sourceRepositorio Institucional Ulima
dc.subjectTiosemicarbazonases_PE
dc.subjectPaladioes_PE
dc.subjectLínea celular tumorales_PE
dc.subjectThiosemicarbazonesen_EN
dc.subjectPalladiumen_EN
dc.subjectCell line, Tumoren_EN
dc.subject.classificationIngenierías / Ingeniería química
dc.titleSynthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lineses_PE
dc.typeinfor:eu-repo/semantics/articlees_PE
dc.type.otherArtículo en Scopuses_PE
dc.identifier.journalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
dc.publisher.countryAlemania
dc.identifier.eissn0939-5075
dc.description.peer-reviewRevisión por pares


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess
Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess