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dc.contributor.authorAndreucci, D.
dc.contributor.authorBersani, Alberto Maria
dc.contributor.authorBersani, Enrico
dc.contributor.authorLeón Trujillo, Francisco James
dc.contributor.authorMarconi, Silvia
dc.contributor.otherLeón Trujillo, Francisco James
dc.identifier.citationAndreucci, D., Bersani, A. M., Bersani, E., León Trujillo, F. J. & Marconi, S. (2022). A 3D mathematical model of coupled stem cell-nutrient dynamics in myocardial regeneration therapy. Journal of Theoretical Biology, 537.
dc.descriptionIndexado en Scopuses_PE
dc.description.abstractStem cell therapy is a promising treatment for the regeneration of myocardial tissue injured by an ischemic event. Mathematical modeling of myocardial regeneration via stem cell therapy is a challenging task, since the mechanisms underlying the processes involved in the treatment are not yet fully understood. Many aspects must be accounted for, such as the spread of stem cells and nutrients, chemoattraction, cell proliferation, stages of cell maturation, differentiation, angiogenesis, stochastic effects, just to name a few. In this paper we propose a 3D mathematical model with a free boundary that aims to provide a qualitative description of some main aspects of the stem cell regenerative therapy in a simplified scenario. The paper mainly focuses on the description of the shrinking of the necrotic core during treatment. The stem cell and nutrients dynamics are described through coupled reaction-diffusion problems. Proliferation, chemoattraction, tissue regeneration and nutrient consumption are included in the model.es_PE
dc.publisherElsevier Ltd.es_PE
dc.relation.ispartofurn:issn: 0022-5193
dc.sourceRepositorio Institucional - Ulimaes_PE
dc.sourceUniversidad de Limaes_PE
dc.subject.classificationPendiente / Pendientees_PE
dc.titleA 3D mathematical model of coupled stem cell-nutrient dynamics in myocardial regeneration therapyes_PE
dc.type.otherArtículo en Scopuses_PE
dc.identifier.journalJournal of Theoretical Biologyes_PE
dc.description.peer-reviewRevisión por pareses_PE

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