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dc.contributor.authorHernández-Gorritti, Wilfredo-Román
dc.contributor.authorPaz-Castillo-Berríos, Juan
dc.contributor.authorVaisberg-Wolach, Abraham
dc.contributor.authorSpodine-Spiridonova, Evgenia 
dc.contributor.authorRichter, Rainer
dc.contributor.authorBeyer, Lothar
dc.contributor.otherHernández-Gorritti, Wilfredo-Románes
dc.contributor.otherPaz-Castillo-Berríos, Juan
dc.date.issued2008
dc.identifier.citationHernández, W., Paz, J., Vaisberg, A., Spodine, E., Richter, R., y Beyer, Lothar. (2008). Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines. Bioinorganic Chemistry and Applications, 2008, 9p. doi:10.1155/2008/690952
dc.identifier.issn1565-3633
dc.identifier.urihttps://hdl.handle.net/20.500.12724/2408
dc.descriptionIndexado en Scopus
dc.description.abstractThe palladium (II) bis-chelate Pd (L 1 - 3) 2 and platinum (II) tetranuclear Pt 4 (L 4) 4 complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB (+) -mass and NMR (1 H, 13 C) spectroscopy. The complex Pd (L 2) 2 [H L 2 = m -CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to Pd II through the nitrogen and sulphur atoms in a transarrangement, while the complex Pt 4 (L 4) 4 [H L 4 = 4 -phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four Pt II ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and their complexes was determined against different human tumor cell lines, which revealed that the palladium (II) and platinum (II) complexes are more cytotoxic than their ligands with IC 50 values at the range of 0.07-3.67 µM. The tetranuclear complex Pt 4 (L 4) 4, with the phenyl group in the terminal amine of the ligand, showed higher antiproliferative activity (CI 50 = 0.07-0.12 µM) than the other tested palladium (II) complexes.
dc.formatapplication/pdfes
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/pe/es
dc.sourceUniversidad de Limaes
dc.sourceRepositorio Institucional Ulimaes
dc.subjectTiosemicarbazona
dc.subjectPaladio
dc.subjectToxicología
dc.subjectDivisión celular
dc.subject.classificationIngenierías / Ingeniería química
dc.titleSynthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lineses_ES
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.type.otherArtículo en Scopuses_PE
dc.identifier.journalBioinorganic Chemistry and Applicationses
dc.publisher.countryEstados Unidoses
dc.identifier.eissn1687-479Xes
dc.description.peer-reviewRevisión por pares


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