Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines
Fecha
2008Autor(es)
Hernández Gorritti, Wilfredo Román
;
Paz Castillo Berríos, Juan
;
Vaisberg Wolach, Abraham
;
Spodine Spiridonova, Evgenia
;
Richter, Rainer
;
Beyer, Lothar
Resumen
The palladium (II) bis-chelate Pd mathematical equation and platinum (II) tetranuclear mathematical equation complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (¿1H, ¿13C) spectroscopy. The complex mathematical equation [HL2 = m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a transarrangement, while the complex mathematical equation [HL4 = 4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and their complexes was determined against different human tumor cell lines, which revealed that the palladium (II) and platinum (II) complexes are more cytotoxic than their ligands with IC50 values at the range of 0.07–3.67¿µM. The tetranuclear complex mathematical equation, with the phenyl group in the terminal amine of the ligand, showed higher antiproliferative activity (CI50 = 0.07–0.12¿µM) than the other tested palladium (II) complexes.URL
https://hdl.handle.net/20.500.12724/2408Temas
Pendiente
Editor
Hindawi Publishing Corporation-
dc.contributor.author
Hernández Gorritti, Wilfredo RománPaz Castillo Berríos, JuanVaisberg Wolach, AbrahamSpodine Spiridonova, EvgeniaRichter, RainerBeyer, Lothar -
dc.contributor.other
Paz Castillo Berríos, JuanHernández Gorritti, Wilfredo Román -
dc.date.issued
2008 -
dc.description.abstract
The palladium (II) bis-chelate Pd mathematical equation and platinum (II) tetranuclear mathematical equation complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR (¿1H, ¿13C) spectroscopy. The complex mathematical equation [HL2 = m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands (L) coordinated to PdII through the nitrogen and sulphur atoms in a transarrangement, while the complex mathematical equation [HL4 = 4-phenyl-1-benzaldehyde thiosemicarbazone] has a tetranuclear geometry with four tridentate ligands coordinated to four PtII ions through the carbon (aromatic ring), nitrogen, and sulphur atoms where the ligands are deprotonated at the NH group. The in vitro antitumor activity of the ligands and their complexes was determined against different human tumor cell lines, which revealed that the palladium (II) and platinum (II) complexes are more cytotoxic than their ligands with IC50 values at the range of 0.07–3.67¿µM. The tetranuclear complex mathematical equation, with the phenyl group in the terminal amine of the ligand, showed higher antiproliferative activity (CI50 = 0.07–0.12¿µM) than the other tested palladium (II) complexes.en_GB -
dc.format
application/html -
dc.identifier.citation
Hernández, W., Paz, J., Vaisberg, A., Spodine, E., Richter, R., y Beyer, Lothar. (2008). Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell lines. Bioinorganic Chemistry and Applications, 2008, 9p. doi:10.1155/2008/690952es_PE -
dc.identifier.doi
https://doi.org/10.1155/2008/690952 -
dc.identifier.eissn
1687-479X -
dc.identifier.isni
0000000121541816 -
dc.identifier.issn
1565-3633 -
dc.identifier.journal
Bioinorganic Chemistry and Applications -
dc.identifier.scopusid
2-s2.0-58149469053 -
dc.identifier.uri
https://hdl.handle.net/20.500.12724/2408 -
dc.language.iso
eng -
dc.publisher
Hindawi Publishing Corporation -
dc.publisher.country
US -
dc.relation.ispartof
urn:issn:1687-479X -
dc.rights
info:eu-repo/semantics/openAccess -
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/4.0/ -
dc.source
Repositorio Institucional - UlimaUniversidad de Lima -
dc.subject
Pendientees_PE -
dc.subject.ocde
https://purl.org/pe-repo/ocde/ford#2.11.04 -
dc.title
Synthesis, characterization, and in vitro cytotoxic activities of benzaldehyde thiosemicarbazone derivatives and their palladium(II) and platinum(II) complexes against various human tumor cell linesen_GB -
dc.type
info:eu-repo/semantics/article -
dc.type.other
Artículo en Scopus -
ulima.cat
OI
