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Indole-3-carbaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and Antibacterial Activities
dc.contributor.author | Carrasco Solís, Fernando Carlos | |
dc.contributor.author | Hernández Gorritti, Wilfredo Román | |
dc.contributor.author | Chupayo, Oscar | |
dc.contributor.author | Celedonio M., Álvarez | |
dc.contributor.author | Oramas Royo, Sandra | |
dc.contributor.author | Spodine, Evgenia | |
dc.contributor.author | Tamariz Angeles, Carmen | |
dc.contributor.author | Olivera Gonzale, Percy | |
dc.contributor.author | Dávalos, Juan Z. | |
dc.contributor.other | Carrasco Solís, Fernando Carlos | |
dc.contributor.other | Hernández Gorritti, Wilfredo Román | |
dc.date.accessioned | 2020-04-23T17:42:29Z | |
dc.date.available | 2020-04-23T17:42:29Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Carrasco Solís, F., Hernández Gorritti, W., Chupayo, O., Celedonio M., A., Oramas Royo, S., Spodine, E.,Tamariz Angeles, C., Olivera Gonzale, P. & Dávalos, J. (2020). Indole-3-carbaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and Antibacterial Activities. Journal of Chemistry. 2020, 1-9. https://doi.org/10.1155/2020/7157281 | es_PE |
dc.identifier.uri | https://hdl.handle.net/20.500.12724/10791 | |
dc.description | Indexado en Scopus | es_PE |
dc.description.abstract | The two-dimensional NMR (in acetone-d6) spectral data revealed that the molecules 1 and 2 in solution are in the cisE isomeric form. This evidence is supported by DFT calculations at the B3LYP/6-311++G(d,p) level of theory where it was shown that the corresponding most stable conformers of the synthesized compounds have a cisE geometrical configuration, in both the gas and liquid (acetone and DMSO) phases. The in vitro antibacterial activity of compounds 1-4 was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Among all the tested semicarbazones, 1 and 2 exhibited similar inhibitory activities against Staphylococcus aureus (MIC = 100 and 150 µg/mL, respectively) and Bacillus subtilis (MIC = 100 and 150 µg/mL, respectively). On the other hand, 3 and 4 were relatively less active against the tested bacterial strains compared with 1, 2, and tetracycline. © 2020 Fernando Carrasco et al. | es_PE |
dc.language.iso | eng | es_PE |
dc.publisher | Hindawi Limited | es_PE |
dc.relation.uri | https://www.hindawi.com/journals/jchem/2020/7157281/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Repositorio Institucional - Ulima | es_PE |
dc.source | Universidad de Lima | es_PE |
dc.subject | Química orgánica | es_PE |
dc.subject | Compuestos orgánicos | es_PE |
dc.subject | Chemistry, Organic | es_PE |
dc.subject | Organic compounds | es_PE |
dc.title | Indole-3-carbaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and Antibacterial Activities | es_PE |
dc.type | info:eu-repo/semantics/article | |
dc.description.version | info:eu-repo/semantics/publishedVersion | |
dc.type.other | Artículo en Scopus | es_PE |
ulima.areas.lineasdeinvestigacion | Calidad de vida y bienestar / Salud | es_PE |
ulima.areas.lineasdeinvestigacion | Recursos naturales y medio ambiente / Materiales avanzados | es_PE |
dc.publisher.country | GB | es_PE |
dc.description.peer-review | Revisión por pares | es_PE |
dc.subject.ocde | http://purl.org/pe-repo/ocde/ford#1.00.00 | |
dc.identifier.doi | https://doi.org/10.1155/2020/7157281 | |
ulima.autor.afiliacion | Carrasco Solís, Fernando Carlos (Facultad de Ingeniería Industrial, Universidad de Lima) | es_PE |
ulima.autor.afiliacion | Hernández Gorritti, Wilfredo Román (Facultad de Ingeniería Industrial, Universidad de Lima) | es_PE |
ulima.autor.carrera | Carrasco Solís, Fernando Carlos (Ingeniería Industrial) | es_PE |
ulima.autor.carrera | Hernández Gorritti, Wilfredo Román (Ingeniería Industrial) | es_PE |
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