Synthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lines
Resumen
With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC1, (1), 4-phenyl-1-
(5
-phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding
palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were
synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human
tumor cell lines have revealed that the palladium(II) complexes 5– 8 are more cytotoxic (IC50 values
in the range of 0.21 – 3.79 µM) than their corresponding ligands (1 – 4) (> 60 µM). These results
indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on
K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 =
0.21 µM).
Cómo citar
Hernández, W., Paz, J., Carrasco, F., Vaisberg, A., Manzur, J., Spodine, E., ... y Beyer, L. (2010). Synthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lines. Zeitschrift für Naturforschung B, (65)10, 1271–1278. https://doi.org/10.1515/znb-2010-1015Editor
Walter de Gruyter GmbHRecurso(s) relacionado(s)
https://doi.org/10.1515/znb-2010-1015Revista
Zeitschrift fur Naturforschung - Section B Journal of Chemical SciencesColeccion(es)
- Ingeniería Industrial [115]